- Prior external beam radiation therapy to the brain or whole brain radiation therapy
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Planned cytotoxic chemotherapy during the WBRT only. Patients may have had prior chemotherapy
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Radiographic evidence of hydrocephalus or other architectural distortion of the ventricular system, including placement of external ventricular drain or ventriculoperitoneal shunt
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Pregnant or lactating women, or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
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Prior allergic reaction to memantine (memantine hydrochloride)
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Current alcohol or drug abuse (may exacerbate lethargy/dizziness with memantine)
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Intractable seizures while on adequate anticonvulsant therapy—more than 1 seizure per month for the past 2 months
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Patients with definitive leptomeningeal metastases
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Patients with brain metastases from primary germ cell tumors, small cell carcinoma, unknown primary, or lymphoma
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Contraindication to magnetic resonance (MR) imaging such as implanted metal devices or foreign bodies
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Contraindication to gadolinium contrast administration during MR imaging, such as allergy or insufficient renal function
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Current use of (other N-methyl D-aspartate [NMDA] antagonists) amantadine, ketamine, or dextromethorphan
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