Skip Navigation Links
A Study to Determine if Identification of Undiagnosed Atrial Fibrillation in People at Least 70 Years of Age Reduces the Risk of Stroke (1411907)
Overall Recruitment Status: Active, currently enrolling
Official Title
GUARD-AF: reducinG Stroke by Screening for UndiAgnosed atRial Fibrillation in Elderly inDividuals
Region Sponsors
California - Northern
Bristol-Myers Squibb Company
Acronym KP IRB No.
GUARD-AF) 1411907
Study Type Phase
Clinical Trial Phase III
Study Population Description
Older adults with no known history of AF or AFL.
The purpose of this study is to determine if a one-time AF detection intervention using a continuous patch-based electrocardiographic monitor for up to 14 days in men and women at least 70 years of age without known atrial fibrillation (AF) or atrial flutter (AFL) reduces the person-years incidence rate of ischemic stroke compared to usual care.
Detailed Description
Randomized pragmatic clinical trial of one-time screening for AF using the Zio XT monitor decreases the risk of ischemic stroke compared with usual care among adults aged 70 years or older who do not a history of AF or AFL.
Gender Age Limit
Male & Female 70 years & older
Inclusion Criteria
  • Men and women at least 70 years of age in primary care practices
  • Willing to provide consent to participate in the study and to provide access to their data from health records
Exclusion Criteria
  • Oral anticoagulation (OAC) for any indication at the time of enrollment
  • History of atrial fibrillation or atrial flutter as documented in the participant's current medical problem list
  • Any condition the investigator considers a contraindication to OAC (for example, bleeding that required medical attention or severe kidney disease)
  • Any condition the investigator considers will prevent compliance with study instructions
  • Implanted cardiac devices (pacemakers, implantable cardiac defibrillators, or cardiac resynchronization therapy, and implantable loop recorders)
  • History of allergy to adhesive

Keywords and/or Specific Medical Conditions
  • Arrhythmias, Cardiac
  • Heart Diseases
  • Atrial Fibrillation
  • Ischemic Stroke
  • Atrial Flutter
  • Pathologic Processes
  • Cardiovascular Diseases
  • Cardiology
  • Electrocardiographic monitoring
KP Clinical Facility
  • All Kaiser Permanente Northern California Medical Centers
Clinical Area
  • Cardiology

Principal Investigator:
Alan S Go, MD
Contact Information:
- Thida C Tan, MPH
-Regional Locations-DOR

Do you want to receive
Email Alerts?

Sign Up Here!

Regional Research Sites: