- Patients with brain metastases are excluded if they meet ANY of the following criteria: Symptoms from brain metastases have not resolved prior to study entry, Five or more clearly identified foci of metastases to the brain, Largest unexcised tumor exceeds 3 cm, Spinal cord metastases, Medical Oncologist plans to employ HER2-directed tyrosine kinase inhibitor as component of systemic therapy, Metastatic disease limited to CNS
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History of systemic anti-cancer therapy
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History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to study entry
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Uncontrolled hypertension
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Cardiac disease (history of and/or active disease), allergies, history of autoimmune disease, immunosuppressive use, active/uncontrolled systemic disease etc. that would preclude the safe use of the drugs included in the treatment regimens and/or safe participation in the study
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