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An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study
Overall Recruitment Status: Enrollment not started
 
Official Title
Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated With Anti-PD-1/Anti-PD-L1 Immunotherapy in a Community Oncology Setting
 
Region Sponsors
Colorado
University of Rochester NCORP Research Base
 
Acronym KP IRB No.
(DiRECT) 1948886
 
Study Type Phase
Prospective Cohort Study with Direct Patient Contact
 
Study Population Description
(Adult, Older Adult) Male and Female - African American or European American patients diagnosed with stage I-IV invasive cancer receiving immune checkpoint inhibitor treatment
 
Purpose
This study compares treatment outcomes between patients of African American/Black (AA) ancestry and European American/White (EA) ancestry currently receiving immune checkpoint inhibitor treatment. Collecting samples of blood and saliva and health and treatment information from racially diverse patients receiving immune checkpoint inhibitor treatment over time may help doctors better understand health care disparities among all cancer patients.
 
Detailed Description
PRIMARY OBJECTIVE: I. To compare incidence of Common Terminology Criteria for Adverse Events (CTCAE) grade 2-5 immune-related adverse reactions (irAEs) between African American (AA) and European American (EA) patients within the first year of starting immune checkpoint inhibitor (ICI) treatment. SECONDARY OBJECTIVES: I. To compare objective response rate (ORR) to ICI treatment between AA and EA patients within the first year of starting ICI treatment. II. To compare health-related quality of life (HRQOL) measured using the Patient Reported Outcomes Measurement Information System (PROMIS) Preference (Patient Reported Outcomes [PRO] Pr) summary score and Functional Assessment of Cancer Therapy-Immune Checkpoint Modulator (FACT-ICM) between AA and EA patients within 1 year of starting ICI treatment. EXPLORATORY OBJECTIVES: I. To compare AA and EA patients on severity (i.e., CTCAE grade) and timing of irAEs within 1 year of starting ICI treatment. II. To assess disease, treatment, individual, and behavioral factors as predictors of grade 2-5 irAEs, and as potential causes of racial differences in irAEs, within 1 year of starting ICI treatment. III. To compare AA and EA patients on long-term outcomes (e.g., progression-free survival [PFS], overall survival [OS], and HRQOL beyond the first year) at the end of the study period. IV. To assess the impact of irAEs and disease, treatment, behavioral, and individual factors on ICI outcomes (ORR, HRQOL, PFS, OS), and as potential causes of racial differences in outcomes, at the end of the study period. V. To compare ICI treatment patterns (e.g., delay and discontinuation of ICI treatment) between AA and EA patients within 1 year of starting ICI treatment. VI. To assess irAEs, treatment, disease, and individual factors, including healthcare barriers, as possible reasons for suboptimal treatment patterns, and as potential causes of racial differences, within 1 year of starting ICI treatment. OUTLINE: Patients' complete questionnaires and undergo collection of blood and saliva samples before 1st and 2nd infusion of immunotherapy, 6 months after 1st infusion of immunotherapy, and then every year after 1st infusion of immunotherapy. Patients also undergo collection of saliva samples before 1st and 2nd infusion of immunotherapy. A tumor sample will also be collected at the beginning of the study and patient's medical records will be reviewed.
 
Gender Age Limit
Male & Female 18 years & older
 
Inclusion Criteria
  • Be 18 years of age or older
  • Self-identify as African/African American/black (AA), or European American/ Caucasian/white (EA) * Patients may identify a Hispanic/Latino ethnicity in combination with an AA or EA racial identity
  • Have a current diagnosis of invasive cancer at stage I-IV
  • Patients may have a history of previous cancer diagnosis and cancer treatment not involving immunotherapy
  • Be scheduled to receive anti-PD-1/-L1 ICI-containing therapy according to Food and Drug Administration (FDA) labels or National Comprehensive Cancer Network (NCCN) guidelines at Category 1 or 2A as standard of care treatment alone or in combination with co-treatments (including alternative ICIs)
  • Be able to speak and read English or Spanish
  • Be able to provide written or remote informed consent
 
Exclusion Criteria
  • Identify as Asian, Pacific Islander, or American Indian/Alaskan Native
  • Be diagnosed with melanoma (because melanoma is very rare in AAs)
  • Currently participate or plan to participate in any other cancer treatment trials
  • Have received prior immunotherapy for cancer, including checkpoint inhibitors, chimeric antigen receptor (CAR)-T therapy, and/or cytokine therapy

 
Keywords and/or Specific Medical Conditions
  • Neoplasms
  • Oncology (Adult)
 
KP Clinical Facility
  • Franklin Medical Offices - Denver
  • Lone Tree Medical Offices - Lone Tree
  • Rock Creek Medical Offices - Lafayette
 
Clinical Area
  • Oncology (Adult)


Principal Investigator:
Alexander Menter, MD
Contact Information:
- Ivana Marchlewicz, MPH
-ivana.a.marchlewicz@kp.org
-Lone Tree Medical Offices - Lone Tree


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