KPStudySearch

A Phase 3, Randomized, Open-label Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced Epidermal Growth Factor Receptor-mutated (EGFRm) Non-small Cell Lung Cancer (NSCLC) After Failure of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) Therapy (HERTHENA-Lung02)

Overall Recruitment Status: Active, not yet recruiting

Official Title

Region

Sponsors

California - Northern

Daiichi Sankyo

Acronym

NCT No.

NCT05338970

Study Type

Phase

INTERVENTIONAL

Phase III

Purpose

Disease progression is typical for patients with epidermal growth factor receptor mutated (EGFRm) non-small cell lung cancer (NSCLC). Standard platinum-based chemotherapy offers limited efficacy and an unfavorable safety profile.There is an urgent need for more effective and tolerable therapies for patients with EGFRm NSCLC who have exhausted available targeted therapies. Clinical evidence suggest that patritumab deruxtecan constitutes a promising investigational therapy for patients with EGFRm NSCLC.

Detailed Description

Inclusion Criteria

Is a male or female subject aged =18 years (follow local regulatory requirements if the legal age of consent for study participation is \>18 years old).

Has histologically or cytologically documented metastatic or locally advanced non-squamous NSCLC not amenable to curative surgery or radiation.

Has documentation of an EGFR-activating mutation detected from tumor tissue or blood sample: exon 19 deletion or L858R at diagnosis or thereafter.

Received 1 or 2 prior line(s) of an approved EGFR TKI treatment in the metastatic or locally advanced setting, which must include a third -generation EGFR TKI

May have received either neoadjuvant and/or adjuvant treatment if progression to metastatic or locally advanced disease occurred at least 12 months after the last dose of such therapy and subsequently experienced disease progression on or after third-generation EGFR TKI treatment administered in the metastatic or locally advanced setting.

Has not received any other prior systemic therapies in the metastatic or locally advanced setting (including chemotherapy, immunotherapy etc) (even if administered in combination with EGFR TKI).

Has documentation of radiographic disease progression while receiving or after receiving a third generation EGFR TKI for metastatic or locally advanced disease.

Has at least 1 measurable lesion as per RECIST v1.1 by Investigator assessment.

Is willing to have a tumor biopsy or provide recently obtained tumor tissue.

Has an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1 at Screening.

Has adequate bone marrow reserve and organ function based on local laboratory evaluation within 14 days prior to randomization:

Platelet count: =100,000/mm\^3 or =100 × 10\^9/L within 14 days prior to the assessment of platelet count during the Screening Period

Absolute neutrophil count: =1500/mm\^3 or =1.5 × 10\^9/L within 14 days prior to the assessment of absolute neutrophil count during the Screening Period

Hemoglobin (Hgb): =9.0 g/dL within 14 days prior to the assessment of hemoglobin during the Screening Period

Creatine clearance (CrCl): CrCl =45 mL/min calculated by using the Cockcroft-Gault equation or measured CrCl

Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT): AST/ALT =3× Upper limit of normal (ULN)

Total bilirubin (TBL): TBL =1.5 × ULN

Serum albumin: =2.5 g/dL

Prothrombin time (PT) or Prothrombin time-International normalized ratio (PT-INR) and activated partial thromboplastin time (aPTT)/partial thromboplastin time (PTT): =1.5 × ULN, except for participants receiving coumarin-derivative anticoagulants or other similar anticoagulant therapy who must have PT-INR within therapeutic range as deemed appropriate by the Investigator

Exclusion Criteria

Has any previous histologic or cytologic evidence of small cell OR combined small cell/non-small cell disease in the archival tumor tissue or pretreatment tumor biopsy, or squamous NSCLC histology

Has any history of interstitial lung disease (ILD) (including pulmonary fibrosis or radiation pneumonitis), has current ILD, or is suspected to have such disease by imaging during Screening

Has clinically severe respiratory compromise (based on the Investigator's assessment) resulting from intercurrent pulmonary illnesses including, but not limited to the following:

Any underlying pulmonary disorder, restrictive lung disease, or pleural effusion

Any autoimmune, connective tissue, or inflammatory disorders where there is documented, or a suspicion of pulmonary involvement at the time of Screening

OR prior complete pneumonectomy Is receiving chronic systemic corticosteroids dosed at \>10 mg prednisone or equivalent anti-inflammatory activity or any form of immunosuppressive therapy prior to randomization Has any history of or evidence of current leptomeningeal disease

Has evidence of clinically active spinal cord compression or brain metastases, defined as being symptomatic and untreated, or requiring therapy with corticosteroids or anticonvulsants to control associated symptoms

Any prior treatment with any agent including an antibody drug conjugate (ADC) containing a chemotherapeutic agent targeting topoisomerase I, human epidermal growth factor receptor 3 (HER3) antibody, and any systemic therapies (other than EGFR TKIs) in the metastatic/locally advanced setting, including chemotherapy or any other systemic therapy in combination with an EGFR TKI

Has history of other active malignancy within 3 years prior to randomization, except for adequately resected nonmelanoma skin cancer, adequately treated intraepithelial carcinoma of the cervix, and any other curatively treated in situ disease

Has uncontrolled or significant cardiovascular disease prior to randomization

Has active hepatitis B and/or hepatitis C infection, such as those with serologic evidence of active viral infection within 28 days of randomization

Has a known human immunodeficiency virus (HIV) infection that is not well controlled

Has clinically significant corneal disease

Keywords and/or Specific Medical Conditions

EGFR exon 19 deletion	U3-1402
EGFR L858R	Nonsquamous Non-small Cell Lung Cancer
HER3-DXd	Oncology (Adult)
Patritumab deruxtecan

KP Clinical Facility

Diablo Medical Center-Walnut Creek
Oakland Medical Center
Roseville Medical Center
Roseville Medical Center-Folsom
Roseville Medical Center-Lincoln
Roseville Medical Center-Rancho Cordova
San Francisco Medical Center
Santa Clara Medical Center-Homestead
Vallejo Medical Center