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- Patients must not have received any cytotoxic chemotherapy for either the current diagnosis of T-ALL, T-L-Ly or for any cancer diagnosis prior to the initiation of protocol therapy on AALL1231, with the exception of:
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- Steroid pretreatment: prednisone or methylprednisolone for =\< 120 hours (5 days) in the 7 days prior to initiating induction chemotherapy or for =\< 336 hours (14 days) in the 28 days prior to initiating induction chemotherapy
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- prior exposure to ANY steroids that occurred \> 28 days before the initiation of protocol therapy does not affect eligibility
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- the dose of prednisone or methylprednisolone does not affect eligibility
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- Intrathecal cytarabine (the CNS status must be determined based on a sample obtained prior to administration of any systemic or intrathecal chemotherapy, except for steroid pretreatment) system chemotherapy must begin with 72 hours of this IT therapy
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- Pretreatment with hydroxyurea
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- 600 cGy of chest irradiation, if medically necessary
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- Pre-treatment with dexamethasone in the 28 days prior to initiation of protocol therapy is not allowed with the exception of a single dose of dexamethasone use during sedation to prevent or treat airway edema
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- inhalation steroids and topical steroids are not considered pretreatment
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- Pre-existing \>= grade 2 sensory or motor peripheral neurotoxicity
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- Uncontrolled seizure disorder
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- Diagnosis of Down syndrome (Trisomy 21)
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- Patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs
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- a pregnancy test is required for female patients of childbearing potential
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- Lactating females who plan to breastfeed
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- Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation
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- Patient has hypersensitivity to bortezomib, boron, or mannitol
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- Serious medical or psychiatric illness likely to interfere with participation in this clinical study
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- Participation in clinical trials with other investigational agents not included in this trial, within 14 days of the start of this trial and within 30 days of any dose of bortezomib
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