- pre-event inability to perform all of own basic ADLs
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unable to obtain informed consent from subject or legally authorized representative
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current mechanical ventilation (can enroll later if this resolves) or tracheostomy
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current use of positive airway pressure, or use within one month prior to stroke
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anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible
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severe bullous lung disease
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history of prior spontaneous pneumothorax or current pneumothorax
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hypotension requiring current treatment with pressors (can enroll later if this resolves)
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other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP
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massive epistaxis or previous history of massive epistaxis
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cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus
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recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure
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current receipt of oxygen supplementation \>4 liters per minute
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current contact, droplet, respiratory/airborne precautions
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