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Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

NCT No.: NCT05612347

Study Type: INTERVENTIONAL

Phase: n/a

Region: California - Northern

Acronym: COOP

Official Title

Colonoscopy Versus Stool-based Testing for Older Adults With a History of Colon Polyps

Purpose

This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.

Detailed Description

Sex

Male & Female

Age Limit

Eligibility Criteria

Inclusion Criteria

* English or Spanish speaking
* Personal history of colorectal polyps
* Most recent colonoscopy with ≤2 non-advanced polyps
* Currently due or coming due within 12 months for colonoscopy
* Able to provide written informed consent

Exclusion Criteria

* Personal history of colorectal cancer
* Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
* Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
* Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
* Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
* Patients unable to provide written informed consent

Keywords and/or Specific Medical Conditions

  • Fecal immunochemical test (FIT)
  • Colonoscopy

Sponsors

  • Dartmouth-Hitchcock Medical Center

KP Clinical Facility

Clinical Area

Principal Investigator

Theodore Levin  

Contact Information

 - CTP Digital Solutions
- CTP-DigitalSolutions@kp.org
- All Kaiser Permanente Northern California Medical Centers

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