- Diagnosis of moderate to severe HS for at least 3 months prior to the screening visit.
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- Total abscess and inflammatory nodule count of at least 5 at both the screening and baseline visits.
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- HS lesions in at least 2 distinct anatomical areas (examples include but are not limited to left and right axilla or left and right inguinocrural fold), 1 of which must be at least Hurley Stage II or Hurley Stage III, at both the screening and baseline visits.
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- Documented history of inadequate response to at least a 3-month course of at least 1 conventional systemic therapy (oral antibiotic or biologic drug) for HS (or demonstrated intolerance to, or have a contraindication to, a conventional systemic therapy for treatment of their HS).
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- Agreement to NOT use topical and systemic antibiotics for treatment of HS during the placebo-controlled period.
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